ESXi hosts enter a non-responsive state, and Virtual Machines (VMs) appear disconnected in the vCenter UI.
The vCenter UI displays warnings: Path redundancy to storage device naa.#### degraded.
From ESXi, var/log/vobd.log there is an event for "Path state changes indicating storage connectivity issues"
2025-05-31T06:03:30.536Z: [scsiCorrelator] 12246182344412us: [vob.scsi.scsipath.pathstate.dead] scsiPath vmhba2:C0:T6:L1 changed state from on
2025-05-31T06:03:30.538Z: [scsiCorrelator] 12246182344611us: [vob.scsi.scsipath.remove] Remove path: vmhba2:C0:T6:L1
2025-05-31T06:03:30.538Z: [scsiCorrelator] 12246182345421us: [vob.scsi.scsipath.pathstate.dead] scsiPath vmhba2:C0:T6:L2 changed state from onvar/run/log/vmkernel.log, the nfnic driver reports target port unavailabilitynfnic: <1>: INFO: fnic_queuecommand: 731: returning IO as lun is inactive or tport is NULL. driverIO:0VMware vSphere ESXi 7.x
VMware vSphere ESXi 8.x
Cisco nfnic driver
The message "returning IO as LUN is inactive or tport is NULL" indicates the ESXi host is unable to process I/O requests because the SAN target port is unavailable or the LUN is administratively inactive.
If the issue persists after storage and fabric remediation, see Contact Support. Scroll to the bottom of the page and click on your respective region.