YYYY-MM-DDTHH:mm:ssZ warning vpxd[#####] [Originator@#### sub=HttpConnectionPool-######] Failed to get pooled connection; <cs p:00007fd6e008efd0, TCP:<FQDN>:443>, SSL(<io_obj p:0x00007fd5c009efd8, h:32, <TCP '127.0.0.1 : 47280'>, <TCP '127.0.0.1 : 443'>>), duration: 2msec, N7Vmacore3Ssl18SSLVerifyExceptionE(SSL Exception: Verification parameters:--> PeerThumbprint: ##:##:##:##:##:##:##:##:##:##:##:##:##:##:##:##:##:##:##:##--> ExpectedThumbprint: --> ExpectedPeerName: <FQDN>--> The remote host certificate has these problems:--> --> * certificate has expired)8.x
There is an expired trusted root certificate preventing vpxd from starting.
Follow the steps outlined in Using vSphere Certificate Manager to Replace SSL Certificates under the section 'Implement Default Certificates (use Option 4 or 8)' to regenerate valid SSL certificates.