GOS, including Windows, Linux and Unix, cannot boot from 4kn disks when using BIOS firmware.
vSphere 9.0 and later
BIOS was designed in an era when hard disk sectors were strictly 512 bytes. Since this sector size is baked into BIOS interfaces, 4kn disks are incompatible.
To boot from 4kn disks, select EFI firmware during installation.