In a scenario where an MTU is set to 9000 on newly added vSAN hosts used for SRM replication and the rest of the cluster is using an MTU of 1500, the following symptoms may be observed on either Prod or DR clusters:
https://knowledge.broadcom.com/external/article?articleNumber=312096
8.0U3
Inconsistent MTU across SRM sites and/or vSAN cluster hosts, SRM specifically requires both Prod and SRM host SRM tagged vmkernel adapters be set to the same MTU
Align MTU across SRM sites and/or vSAN cluster hosts, if large MTU (jumbo frames) are required they need to be set end-to-end as noted in the following vSphere networking documentation:
The specific vSAN and SRM tagged interfaces might be different, so symptoms may differ depending on the specific network configuration. Note if the SRM vmkernel adapter isn't tagged with "vSphere Replication traffic", then replication will occur over the Management tagged vmkernel adapter. vSAN traffic will only run across vSAN tagged vmkernel adapters.
Reference KB on troubleshooting RPO violations: https://knowledge.broadcom.com/external/article?articleNumber=312689