VMware vSphere ESXi 7.x
VMware vSphere ESXi 8.x
The loss of connectivity to the storage device is causing the datastore to be inaccessible. The error "vmhba##:C#:T#:L# (PERM LOSS)" indicates that the ESXi host is unable to communicate with the device at the specified path due to a permanent loss of connection. This can be caused due to a problem with the storage device or LUN.
vmkernel: cpu#:2097648)VMW_SATP_ALUA: satp_alua_issueCommandOnPath:1019: Path "vmhba##:C#:T#:L#" (PERM LOSS) command 0xa3 failed with status Device is permanently unavailable. H:0x0 D:0x2 P:0x0 Valid sense data: 0x5 0x25 0x0.
Hostd[2099261]: --> value = "naa.##############################"
Hostd[2100061]: [Originator@6876 sub=Vimsvc.ha-eventmgr] Event 338 : Lost connectivity to storage device naa.##############################. Path vmhba##:C#:T#:L# is down. Affected datastores: Unknown.
It is advised to contact the storage vendor to investigate the PDL
For more detail on APD/PDL please refer below KB article.
Permanent Device Loss (PDL) and All-Paths-Down (APD) in vSphere ESXI
Path Redundancy to Storage Device Degraded message on the ESXi host