vSphere Replication not able to login | UI error: Unable to read configuration

Products

• VMware vSphere ESXi

Issue/Introduction

• vSphere Replication 8.6 errors in the GUI
• Unable to ping or reach the remote site over port 443
• Unable to reconnect site pair

Error:
vSphere Replication - UI error: Unable to read configuration

Environment

vSphere Replication 8.x

Cause

The route for the secondary NIC is not configured properly. Essentially, networking issues between the two sites. 

Resolution

1. Ensure all required replication ports are open see KB Port numbers that must be open for vSphere Replication 8.x
2. Power cycle the vSphere Replication Appliance (Power off, then power on. Not reboot)
3. Reconfigure the VRMS appliance through the VAMI interface on port 5480
4. Login and check connection
5. Edit /etc/systemd/network/10-eth0-network
6. Add the 'Destination' network into the file. See KB Configure a Static Route on an Additional VM Network Adapter
7. Restart the network - systemctl restart systemd-networkd