The error that is being returned is a 400 Client Error message when attempting to authenticate with the assigned SEPM username and password. The same account can successfully log into the SEPM without issue.
Found in the semapisrv_log.<date>.log:
[https-openssl-nio2-0.0.0.0-8446-exec-6] ERROR c.s.s.s.c.e.h.GlobalControllerExceptionHandler - EXCEPTION: Account is locked or invalid username, password, or domain. com.symantec.sepm.core.exception.InvalidArgumentException: Account is locked or invalid username, password, or domain.
A mismatch in the API files has occurred.