This KB article is written to address Deduplication and compression capacity savings estimation related queries on a vSAN cluster
VMware vSAN 7.0.x
VMware vSAN 8.0.x
Because the domain for deduplication is at the disk group level, a smaller number of large disk groups typically yield higher overall deduplication ratios than a larger number of smaller disk groups.
The disadvantage of having a smaller number of large disk groups is less write-buffer capacity relative to disk group size and more data migration and resync traffic during maintenance operations (disk replacement, failure).
If application-based (e.g., database) native compression is used, vSAN compression may provide reduced benefits.
The space saving obtained due to deduplication and compression is highly dependent on the application workload and data set composition.
therefore it is very difficult to estimate what the Deduplication and Compression savings would be without actually turning the feature on, since the vSAN storage solution deduplication and compression feature provides a varying amount of reduction in capacity depending upon the workload and vSAN disk group configuration.
FYI Dedup and Compression can be enabled on an existing vSAN All Flash OSA Cluster with a valid license that support this feature provided you have enough free space (e.g at least 30% free capacity)
For more information please see this document Enable Deduplication and Compression on Existing vSAN Cluster
Also other option would be just using compression only which will still give you some space savings but it all depends upon data type.
for more information please also see