Traffic from VMs get blocked by Cisco Umbrella firewall.
VMware NSX 4.x
Cisco secure client with following installed modules
AnyConnect VPN 5.1.2.42
Customer Experience Feedback 5.1.2.42
Secure Client UI 5.1.0.1047
Umbrella 5.1.2.42
The issue occurs to VMs connected to NSX segment. No issue with the VM connected to distributed port group.
The reason for this behavior is that the attempt to connect Cisco secure client fails as a result the Cisco Umbrella firewall stops forwarding traffic from the VM where connectivity was broken.
Allow Non-IP traffic by disabling "Block Non-IP Traffic" within NSX segment security profile.