After upgrading VCSA to 8.0 U2 it may function normal for weeks and then start randomly experiencing vpxd service crashes throughout the day.
vCenter Server 8.0 U2
VCF 5.1.x
When vCenter tries to manage datastore files, authorization fails or shows as anonymous.
Upgrade VCSA to 8.0 U3, as this includes the fix. There is no workaround for the issue.
If running VCF 5.1.x it is recommended to upgrade VCF to at least 5.2 and then upgrade VCSA to latest 8.0 U3 build.
Applying individual product updates to VMware Cloud Foundation environments using Async Patch Tool (AP Tool) - Choose the latest build of VCSA supported by 5.1.x you are able to for your environment.