-- Windows guest VM running on a host prepared for NSX.
-- Performance issue seen on Windows guest VMs where VMware NSX Guest Introspection drivers are installed alongside iVanti AMFilesystemFilter driver.
-- Closing Microsoft office applications especially when working with files from OneDrive can take longer than usual time.
-- VMTools NSX Guest Introspection
-- This can happen due to interoperability issues between NSX File Introspection driver (vsepflt) and iVanti AMFilesystemFilter driver.
-- File system filter drivers have assigned altitudes in the system. Changing iVanti AMFileSystemFilter driver altitude helps in resolving this issue.
Refer: How to change the altitude for AMFileSystemFilter driver.