According to IBM documentation, JES2 has only z11 mode on z/OS V2.1 or higher level.
So, the questions being asked are:
1) Can CA Disk work in JES2 z11 mode environment without problem?
2) If CA Disk supports JES2 z11 mode, is it necessary to do some customization in CA Disk?
1) Yes, there is no impact with CA Disk and JES2.
2) CA Disk works fine with z11 mode and nothing needs to be done in CA Disk setup to support it.
As always, please contact CA Technologies support for CA Disk if you have further questions.