Emails are queuing up upstream from DLP.
Logs show that messages fail after 20 seconds.
Request Processor logs show:
All forward hosts unavailable (tid= cid=<> reason=No available forward hosts)
20 seconds indicates we are likely encountering the timeout:
RequestProcessor.ForwardConnectionTimeout
If no MTA accepts our outbound connection in that time, we will return 'No available forward hosts'
Verify that messages are being sent to the desired MTA with Wireshark or Use tcpdump to do a packet capture.
If outbound connection attempts look correct, follow up with the owner/vendor of the upstream MTA.
If this issue occurred after a mail-flow change, it is likely that the IP used in the new configuration may not be accepted by the upstream MTA as a valid sender.