If the connection between the NSX Manager and vCenter is lost for an extended period due to vCenter upgrade failure or other reasons, the Logical Ports will be deleted from the NSX Manager, resulting in the following behaviors.
VMware NSX-T Data Center, VMware NSX
Two conditions need to occur for a deletion of the LP's to take place.
This resulted in bulk number of LP's to be deleted and can't apply firewall rules to the nic. This causes unpredicted blocks, drops, and possibly black-holed traffic as failed closed is applied to all the dfw interfaces by default.
This issue has been fixed in NSX-T 4.2.0 or higher. The workaround is to vMotion the affected VMs.