When creating a VM in VMware Cloud Director, CD automatically assigns a MAC address to the VM to ensure that the MAC address is unique within the environment the CD uses the instance ID of the CD installation to define the MAC address range.
Cloud Director overrides MAC vCenter Server assignments.
The VM MAC address can be changed via CD API below using an API tool like Postman.PUT https://cloud.example.com/api/vApp/vm-ID/networkConnectionSection/
For more information see the Cloud Director API Reference.