IBM reported as follows.
If the "SIIS" assembler instruction is used in a program on z13 or upper processers, CPU time can increase.
Reference materials are as follows:
Identifying “Store Into Instruction Stream” (SIIS) Inefficiency by Using CPU MF Counters
Is there any impact for Endevor?
Release : 18.0 above
Component : Endevor
Endevor supports z15/z16 and there have been no reported problems with SIIS and no specific impact to date.