You can disable the running of any VIX API guest operations by adding the following line to the config file:
guest.commands.enabled = "FALSE"
Placing this line in the virtual machine's VMX file affects only that guest. Placing this line in the host-wide configuration file affects all guests on that host. On ESX/ESXi hosts this file is /etc/vmware/config.
This line also disables the operation of VMware Consolidated Backup (VCB) and VMware Update Manager (VUM), both of which call the VIX API for guest operations.