When performing a vMotion you see this compatibility error in the "Select networks" page of the vMotion wizard:
Unable to migrate from <source server> to <destination server>: "Currently connected network interface" '<device>' cannot use network '<network>', because "the destination host is configured for different offload or security policies than the source network on the source host".
VMware vSphere ESXi 7.x
VMware vCenter Server 7.x
VMware vSphere ESXi 8.x
VMware vCenter Server 8.x
NOTE: The above steps are specifically for standard switches and portgroups, as the settings for a distributed switch (vDS) and distributed portgroup (dPG) is the same between hosts. If migrating a VM between vDS instances, the settings only need to be checked at the portgroup level (vCenter -> Networking page -> right-click the dPG -> Edit Settings) on both the source and destination portgroups.
Again, if a change is needed to be made, it is generally safe to do live. That being said, since a change on a vDS will be implemented on any host using the dPG, it is recommended to make the change in a maintenance window to prevent any possible downtime or packet loss.
For more information related to configuring security policies on the standard switch, please refer : Configure the Security Policy for a vSphere Standard Switch or Standard Port Group