When performing a vMotion you see this compatibility error in the "Select networks" page of the vMotion wizard:
Unable to migrate from <source server> to <destination server>: "Currently connected network interface" '<device>' cannot use network '<network>', because "the destination host is configured for different offload or security policies than the source network on the source host".
NOTE: The above is specifically for standard switches and portgroups, as the settings for a distributed switch (vDS) and distributed portgroup (dPG) is the same between hosts. If migrating a VM between vDS instances, the settings only need to be checked at the portgroup level (vCenter -> Networking page -> right-click the dPG -> Edit Settings) on both the source and destination portgroups.
Again, if a change is needed to be made, it is generally safe to do so live. That said, since a change on a vDS will be implemented on any host using the dPG, it is recommended to make the change in a maintenance window to prevent any possible downtime or packet loss.