VMware vSAN (all versions)
vSAN is designed to work best with 4k aligned I/O (4k, 8k, 16k, 32k, 64k, etc) from guests. When I/O is not aligned to a 4k size, additional I/O operations are required at the vSAN layer before the write can be completed. This adds time (latency) until these operations are completed.
You may use I/O Insight to determine if non-alignment is a factor by looking at the I/O patterns of specific VMs.