NUMA settings can change on a per host or per virtual machine basis in ESXi hosts verion 4.1.x and newer
For memory latency sensitive workloads with low processor utilization or high interthread communication, use hyper-threads with fewer NUMA nodes instead of full physical cores spread over multiple NUMA nodes.
Configure virtual machines to use hyper-threading with NUMA.
VMware vSphere ESXi
Perform either of the following tasks: