Physical NIC Maximum MTU limitation based on the type of the NIC may vary. If the configured MTU value on a vSwitch is greater than the maximum MTU value supported by the up-link physical NIC card then dropped packets may occur.
To resolve this issue, configure the VMNIC MTU based on the manufacture supported MAXMTU. The sent packets must be within the MTU boundary. This is applicable for ESX 3.5 and later.
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