The issue commonly occurs under the following conditions:
VMware NSX-T Data Center 2.5.x
VMware NSX-T Data Center 3.x
Prior to NSX-T 3.x, the IP address and port were evaluated. When this issue occurs in 3.x, this evaluation fails to consider the destination port, therefore it can not make a match on the rule and the connection fails.
This issue is resolved in VMware NSX-T Data Center 3.1.2
Workaround:
Upgrade to NSX-T 3.1.2 where the correct evaluation of the header occurs for the load balancer rule.