When policy routing is configured with HCX and you are doing an In-Place upgrade, this can trigger a PSOD on the ESXi host. Note: For further details on HCX policy routing Mobility Optimized Networking Policy Route
Resolution
This is a known issue impacting NSX-T data center.
Workaround:
When doing the NSX-T upgrade, instead of an in place upgrade, use maintenance mode for the ESXi hosts upgrade. or In HCX if possible, you can disable the policy routing before the upgrade.