The issue arises due to the absence of a custom Compute Profile within the Reservation Mode
This is a Known Issue in VMware Cloud Director 10.3.x.
This issue is resolved in VMware Cloud Director 10.4 available at Broadcom Download Portal
Workaround:
Virtual Machines within a Reservation Model have their reservation values set manually.
To revert the Virtual Machine to it's desired state after making a change to the attached hard disk, manually set the memory reservations to the intended value.