Symptoms:
After upgrading ESXi Host specifically to 7.0U2, Default Gateway details under IPv6 goes missing.
esx.conf file.ConfigStore Database.esx.conf file will be deleted. Where the IPv6 Default Gateway entry doesn't migrate to ConfigStore Database automatically.This issue has been fixed in VMware ESXi 7.0 Update 3c or later.
Workaround:
Follow Set Up IPv6 on an ESXi Host to add IPv6 Gateway manually.