Virtual machines may observe a disproportionate number of interrupts focused on vCPU0 (CPU0 within the Guest OS). Additional symptoms are (and not limited to):
The conditions for this situation are more frequent (but not limited to):
VMware vSphere 6.x
VMware vSphere 7.0.x
VMware recommends to upgrade to at least vSphere ESXi 7.0 Update 2 to allow enhanced performance improvements, as well as code fixes that address the above behaviour. There is no fix available in vSphere 6.x.
For virtual machines with a VMXNET3 adapter allocated, it is recommended to enable RSS per KB article: Poor network performance or high network latency on Windows virtual machines