Symptoms:
In the vmkernel logs, you see error message similar to:
YYYY-MM-DDT23:39:13.460Z cpu30:2097385)WARNING: Heartbeat: 849: PCPU 2 didn't have a heartbeat for 8 seconds; *may* be locked up.
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)ALERT: NMI: 694: NMI IPI: RIPOFF(base):RBP:CS [0x107c73d(0x42001b400000):0x3658:0xf48] (Src 0x1, CPU2)
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9b320:[0x42001c47c73c]Res6AffMgrComputeSortIndices@esx#nover+0x359 stack: 0x430eedde6670
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9b3b0:[0x42001c483e46]Res6AffMgrGetCluster@esx#nover+0xb1f stack: 0xd
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9b4b0:[0x42001c485491]Res6AffMgr_AllocResourcesInt@esx#nover+0x40a stack: 0x430eef635d60
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9b680:[0x42001c4860e2]Res6AffMgr_AllocResources@esx#nover+0x1b stack: 0x0
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9b6c0:[0x42001c4387cc]Fil3_AllocateBlocksVMFS6@esx#nover+0x2ad stack: 0x0
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9b780:[0x42001c43f267]Fil3PlugFileHoleIntVMFS6@esx#nover+0x4ac stack: 0x430ef013ea00
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9b8b0:[0x42001c43f9a1]Fil3_PlugFileHoleTxnVMFS6@esx#nover+0x5a stack: 0x430eeddf1000
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9b920:[0x42001c403d6a]Fil3_FileIOInt@esx#nover+0x1adb stack: 0x4538866a1980
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9bca0:[0x42001c406dde]Fil3_FileIOIntWithRetry@esx#nover+0xe7 stack: 0x0
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9bd40:[0x42001c4070c2]Fil3_FileIOLegacy@esx#nover+0x137 stack: 0x34d6b90787726
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9be40:[0x42001b4397ab]FSSVec_FileIO@vmkernel#nover+0x20 stack: 0x43079572eb90
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9be60:[0x42001b4370c0]FSSFileIO@vmkernel#nover+0x1dd stack: 0x0
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9bec0:[0x42001b437231]FSS_AsyncFileIO@vmkernel#nover+0xe stack: 0x0
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9bee0:[0x42001b4509b3]LibAIODoAsyncIO@vmkernel#nover+0x74 stack: 0xffff8002e7932300
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9bf20:[0x42001b4d1e91]HelperQueueFunc@vmkernel#nover+0x29e stack: 0x430795681308
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9bfe0:[0x42001b769481]CpuSched_StartWorld@vmkernel#nover+0x82 stack: 0x0
YYYY-MM-DDT23:39:13.460Z cpu2:2189304)0x453895d9c000:[0x42001b4be69f]Debug_IsInitialized@vmkernel#nover+0xc stack: 0x0