NSX Manager connectivity is lost when powered off and migrated to another host prepared cluster.
This issue occurs because the NSX Manager is in the list of excluded VMs for Distributed Firewall by default. The NSX Manager sends the list of excluded VMs that reside on a given cluster to hosts of that cluster. NSX Manager keeps track of VMs that are moved from one cluster to another and sends this information to hosts upon VM migration.
But if the NSX Manager is powered off, there is no communication between the hosts and the NSX Manager to send the updated exclude list down to the migrated cluster. When the NSX VM is migrated, it ends up having a DFW filter and existing DFW rules will be applied disrupting the NSX Manager communication.
VMware recommends NOT to deploy the NSX Manager inside a host prepared cluster.
To avoid getting into this issue before migrating the NSX Manager VM to another host prepared cluster, one of the these workaround applies.
This issue is resolved in VMware NSX for vSphere 6.4.0.
Workaround: