To remediate VMSA-2021-0021 on a VMware Cloud Foundation 4.x environment follow the below steps:
Starting with VCF version 4.4.1, the SDDC Manager no longer manages the upgrades of vRealize Operations (even if it was originally deployed via SDDC Manager). For more information, see VMware Cloud Foundation 4.4.1 Release Notes
Upgrade first to VCF 4.4.1 or higher.
Use the SDDC Manager to upgrade vRealize Suite Lifecycle Manager to version 8.6.2 or higher.
Use the vRealize Suite Lifecycle Manager to upgrade vRealize Operations to version 8.6.0 or higher