Symptoms:
Workaround:
To workaround this issue for VDI VMs in ESXi 6.0, use any of the below workarounds
Workaround 1
Check and attempt to repair the disk.
Workaround 2
Disable ATS heartbeat for all hosts.
Refer the article for Disabling ATS heartbeat, ESXi host loses connectivity to a VMFS3 and VMFS5 datastore (2113956)
Workaround 3
Reclaim Disk Space in Horizon
Most other issues with the LookupandOpen[file] can be resolved by following
For more information about troubleshooting VMs which won't power on:
Failed to power on virtual machine