This issue occurs because the host profile attempts to configure settings on a pseudo physical NIC, vusb0, on the ESX host. However, the pseudo NIC does not allow changes to the configuration settings.
To workaround this issue:
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Right-click the profile and click Edit Profile.
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Navigate to the Physical NIC configuration of the network configuration.
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Check the name of the physical NIC to find the physical NIC configuration profile for vusb0.
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Right-click the physical NIC configuration profile and click Remove Profile.