Symptoms:
After upgrading the NSX Edge from 6.2.2 to 6.2.3 and later, these symptoms can be seen:
This is by design.
Starting with NSX for vSphere 6.2.3 and later versions, TLSv1 has been disabled by default as part of NSX for vSphere security enhancements.
To enable TLSv1, it is needed to add an application rule enable tlsv1 and associate it with virtual server manually after upgrading.