This issue occurs when a process locks the /etc/vmware/esx.conf file and does not release the lock, causing the next process that attempts to update and lock the file to fail.
When updating the ESX configuration (and thus the esx.conf configuration file), you create a lock file /etc/vmware/esx.conf.LOCK and link it to the process attempting to lock the file. If the link (known as a symlink) is not valid, it prevents the esx.conf from being unlocked.