This issue occurs due to lack of Low Memory in NUMA node. When virtual machines with a small usage of memory are running on ESXi host, virtual machines are balanced between each NUMA nodes.
However, when a virtual machine using large amount of memory runs on a NUMA node (such as NUMA node 0), it uses up the Low Memory mapped to NUMA node. In this case, VMkernel fails to get network heap from Low Memory space for the connection to the NAS datastore. Thus, the connection goes into APD state.