This document discusses problems with the software iSCSI stack that can be resolved by restarting the stack instead of rebooting the entire ESX system.
This may be necessary when the detection of storage at boot time fails to acquire the iSCSI targets from the array or when the iSCSI stack stops responding.
Symptoms:
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Storage disappeared unexpectedly.
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Storage is missing after a reboot of the ESX host.
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Change to the initiator name (IQN) does not appear to have been accepted.