When using e1000 NIC with RedHat Enterprise Linux 5.x virtual machines, you experience these symptoms:
/var/log/messages
log file of the Linux guest operating system, you see the error:kernel: irq <###>: nobody cared (try booting with the "irqpoll" option)
# rmmod e1000
# modprobe e1000
As an alternative workaround, try adding another vNIC with a VMXNET as an adapter type, then removing the one that is using the e1000 network driver.