The initial upgrade to Server version 8.10.2/8.10.4 and higher require a table restructure during the upgrade process; this causes a longer than usual upgrade time.
The upgrade time is highly variable and is dependent on the number of antibody instances, the count of yara tags, and the SQL resources.
If already on Server version 8.9.4+, Support could provide a manual script to perform the table transformation. For some customers this could be 2-3 times faster than the normal upgrade. Please open a support case to request more information.