Yes, when custom certificates are associated with the sensor's group. The cb.exe process has the rights and ability to update the C:\Windows\System32\Drivers\etc\hosts file by default. The two SANs (Subject Alternative Names) from the custom certificate are needed in the Windows hosts file which are used as the SNI (Server Name Indicator) in the TLS sensor-to-server communications.
Example of hosts file with legacy certificates (hosts file is not changed):
Example of hosts file using custom certificates:
On a standalone EDR server using custom certificates, the IP addresses match that of the Primary server.
Custom certificate's SANs section: