The Symantec Malware Analysis can be integrated with Content Analysis appliance and be dedicated to sandboxing.
In some occasions integration may result in an error:
"Server failed test" - statusCode = 500
When observing CAS logs a similar error can be noticed:
ERROR : SandboxingExample::PerformRequest: SendGetRequest authentication failed with HTTP code 401 on https://#.#.#.#:8082/rapi/system/health_stats/queues
Where "#.#.#.#" is Malware Analysis IP address.
Regenerate Malware Analysis API keys and update Content Analysis configuration as per: Configure a Malware Analysis Sandbox.