Noticed under the Application Windows system event logs, there were many error messages similar to the following:
DCOM was unable to communicate with the computer ***.***.*** using any of the configured protocols; requested by PID *** (D:\***\Notification Server\Bin\AeXSVC.exe).
ITMS 8.5
Found that port 135 was being blocked so unblocked this.
NOTE: Refer to KB listed below to ensure the need ports for AeXSVC are opened.
184952 "Ports and Protocols for Symantec IT Management Suite (ITMS) 8.x"