We an APM agent installed and integrated in WebSphere. We discovered that the WebSphere SOAP port has SSL handshake errors. This issue is on 14 out of the 20 application servers.
Removing APM Agent temporarily and tested the SOAP port by running wsadmin.sh script and that fixed the issue.
Release : 22.1
Using the Cloud Proxy solved the issue. The environment was using TLS 1.1 instead of TLS 1.2.