When configuring the email relay and doing tests, it generates a tls error, according to the documentation, tlsv1_2 was activated but the error is still being obtained:
Release : 14.4
In addition to set SMTP on Vapp do you need to enable the TLS on client as per the link below
https://learn.microsoft.com/en-us/mem/configmgr/core/plan-design/security/enable-tls-1-2-client