Are there considerations that they should be taken into count on having multiple NICs on the SMP server, and if issues are seen if one of those NICs hasn't been configured for communication with SQL server, clients, and site servers?
ITMS 8.6, 8.7
NOTE: This article is not intended to be an official support statement but a quick reference of what we have seen on some simple testing.
After tests on an ITMS VM machine where a 2nd network adapter was added no problems were seen, because:
NOTE: In the case of "Microsoft Load Balancer" usage on the Notification Server, this might cause unnecessary work on client computers and unnecessary sending of basic inventory, since SMA detects NS IP changes very often (Probably sometimes the same could appear if NS has multiple network adapters and client computer will resolve NS hostname by different IP addresses, therefore I would not suggest using multiple NIC on NS and first identify current problems "NS too busy" etc)
Example of a client computer which communicating with ITMS where MS Load balancer is running:
We have the functionality to control downloading from NS (allow/disallow) so client computers will never download packages from NS (only Package Servers can still download from NS) as well as to control overall transfer size to avoid 100% NIC usage:
All current downloading and history can be viewed using default reports (under Reports>Notification Server Management>Server>Subnets and Sites Info):
170157 How to exclude one or more NICs from the basic inventory if the endpoint has multiple NICs?