WPR indicates sysfer.dll being top contributor in leaking pool tags:
Endpoint Protection (SEP) 14.3 RU4 ( Build: 14.3.7393.4000 )
OS : Windows Server 2016/2019 64 bit
This issue is caused due to User Mode EFA failing in Sysplant and it leaks file handles.
This issue is fixed in SEP 14.3 RU5.
Workaround : Disable Sysplant from registry on one system and see if that helps.
HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\SysPlant
value name "Start" and the DWORD value "4".
[Note : Backup the Windows registry before making any change].
In the next reboot the Driver should not load.
If there are more systems, HI policy can be used to make the above registry change.