When certain compressed files are being submitted to be scanned by a 3rd party application (via ICAP) the SPE server was returning a warning indicating that the process didn't go through, or didn't succeed.
A look at the log entry on the SPE server at the same time the scan failed and registered a failure with the application-- a warning was found in the SPE logs in reference to the file name under the "File Policy (Maximum Size)" column.
File Attribute Violation
Release : 8.2.2
The file size was considered too large to pass the MaxFileSize setting without adjusting it.
The size of the file was 1.9GB so running the following command on the SPE server corrected the problem by adjusting the maximum file size allowed to 2GB
Linux: From /opt/SYMCScan/bin
./xmlmodifier -s //filtering/FileAttribute/MaxFileSize/@value 2097152000 filtering.xml
Windows: ".\Program Files\Symantec\Scan Engine\
xmlmodifier -s //filtering/FileAttribute/MaxFileSize/@value 2097152000 filtering.xml