Due to Security hardening practice and NTLM V1's security your environment would like to disable NTLM V1 support in favor of NTLMV2.
What NTLM versions are supported in SEPM/SEP communications?
NTLM v2 support has been enabled since SEP Version 12 Ru2 (Fix ID: 2682376 / 2845764)
Disabling V1 should not cause problems in the SEPM. However there is a possibility you’ll have to re-run the SEPM configuration wizard if it was set to use NTLM 1 originally.