You need to upgrade EEM to EEM 12.6.3 with TLS1.2 enabled
Steps to take before applying SOI 4.2 CUM3
1) Make a backup copy of the whole SOI folder
2) Make a backup of the SOI DB if not already done so.
3) Stop all SOI Services (Manager, UI, Connector using Integration Services)
4) Apply SOI 4.2 CUM3
For more details, please see this link
NOTE: After applying this patch, the SOI Manager will take longer to come online the first time.