For Spectrum, it's the whole install directory, as stated in the docs
To avoid database corruption, exclude DX NetOps Spectrum installation areas and DX NetOps Spectrum files from scans by any local or remote instances of antivirus software. DX NetOps Spectrum installation areas include OneClick and Report Manager installation areas
Exclude all DX NetOps Spectrum installation areas, including OneClick and Report Manager installation areas, from scans by data backup programs.
For CABI, the folwer where the dtabase is installed