You noticed that the clients are updated with the latest definitions, however the SEPM is not showing the updated information in the SEPM\Clients Tab.
exsecars.log shows below error.02/10 10:24:02 [7576:12020] Force to update the USN for agent id: 769EEE8486921EF446063F8E7C2B892D 02/10 10:24:18 [7576:12020] Open File failed! File: 'E:\APPS\Symantec\Symantec Endpoint Protection Manager\data\inbox\agentinfo\75238adb-eedf-4165-9168-9f39e9cc2ebe.tmp' ÉÂ02/10 10:24:18 [7576:12020] ProcessAgentInfo error--Write File Error.!02/10 10:25:46 [7576:12020] Open File failed! File: 'E:\APPS\Symantec\Symantec Endpoint Protection Manager\data\inbox\agentinfo\51b90408-6c68-4fb1-bdc9-23ecf2b0f23c.tmp' ÉÂ02/10 10:25:46 [7576:12020] ProcessAgentInfo error--Write File Error.!
2/20/2022 2:17:15 AM System Error Ntfs AMSDC1-V-54510.ShellECZ.com NT AUTHORITY\SYSTEM 55 *"A corruption was discovered in the file system structure on volume E:The Master File Table (MFT) contains a corrupted file record. The file reference number is 0x900000000000ae. The name of the file is ""\APPS\Symantec\Symantec Endpoint Protection Manager\data\backup.oldd\2020-Dec-14_03-00-06.zip""."2/19/2022 2:58:22 AM System Error Ntfs AMSDC1-V-54510.ShellECZ.com NT AUTHORITY\SYSTEM 55 "A corruption was discovered in the file system structure on volume E:.The Master File Table (MFT) contains a corrupted file record. The file reference number is 0x17b000000000102. The name of the file is ""\APPS\Symantec\Symantec Endpoint Protection Manager\tomcat\bin\semapisrv.log""."Fix the disk Issue Or, move the SEPM to C:\ using disaster recovery process.
Disaster recovery best practices for Endpoint Protection
https://techdocs.broadcom.com/us/en/symantec-security-software/endpoint-security-and-management/endpoint-protection/all/Managing-management-servers-sites-and-databases/disaster-recovery-best-practices-for-endpoint-prot-v18588940-d15e2803.html