XCOMM0402I REQUEST NUMBER 002543 ASSIGNED TO TRANSFER REQUEST
XCOMM1467I OMVS EDC8128I Connection refused. (errno2=0x769F0442)
XCOMM0780E Txpi 215: Socket send error return value = 1128
XCOMM0783E FLUSH REQUEST ENDED DUE TO TCP/IP ERROR
Release : 12.0
Component : XCOM Data Transport for z/OS
Support confirmed with in-house test that the error message sequence generated is the result of the partner XCOM on VSE not being started/available. That was confirmed as being the root cause